Leslie's first company, Value Health Sciences, was a big success and ultimately became part of a multi-billion dollar publicly traded company. From there, he realized the way to build successful businesses was to focus on an overlooked niche. Whenever he starts a new company, he finds a small niche that is being overlooked by the big players. As an entrepreneur, he said you're going to be playing the game with people who have more resources, more capacity to survive, and more capabilities than you're ever going to have. Following his own advice, he's now building his fourth company by focusing on delivering private healthcare to people of means who are willing to work outside the traditional medical system.